Scientists have developed a new contact lens which releases drugs into the eye and could help treat glaucoma, the world's leading cause of irreversible blindness.
Researchers at Harvard Medical School Department of Ophthalmology and the Massachusetts Institute of Technology are one step closer to an eye drop-free reality with the development of a drug-eluting contact lens designed for prolonged delivery of latanoprost, a common drug used for the treatment of glaucoma.
"In general, eye drops are an inefficient method of drug delivery that has notoriously poor patient adherence. This contact lens design can potentially be used as a treatment for glaucoma and as a platform for other ocular drug delivery applications," said Joseph Ciolino, lead author of the paper.
The contacts were designed with materials that are FDA-approved for use on the eye, researchers said.
The latanoprost-eluting contact lenses were created by encapsulating latanoprost-polymer films in commonly used contact lens hydrogel.
"The lens we have developed is capable of delivering large amounts of drug at substantially constant rates over weeks to months," said Professor Daniel Kohane, director of the Laboratory for Biomaterials and Drug Delivery at Boston Children's Hospital.
In vivo, single contact lenses were able to achieve, for one month, latanoprost concentrations in the aqueous humour that were comparable to those achieved with daily topical latanoprost solution, the current first-line treatment for glaucoma, researchers said.
The lenses appeared safe in cell culture and animal studies. This is the first contact lens that has been shown to release drugs for this long in animal models.
The newly designed contact lens has a clear central aperture and contains a drug-polymer film in the periphery, which helps to control drug release.
The lenses can be made with no refractive power or with the ability to correct the refractive error in near sided or far sided eyes.
"A non-invasive method of sustained ocular drug delivery could help patients adhere to the therapy necessary to maintain vision in diseases like glaucoma, saving millions from preventable blindness," Ciolino said.
Researchers at Harvard Medical School Department of Ophthalmology and the Massachusetts Institute of Technology are one step closer to an eye drop-free reality with the development of a drug-eluting contact lens designed for prolonged delivery of latanoprost, a common drug used for the treatment of glaucoma.
"In general, eye drops are an inefficient method of drug delivery that has notoriously poor patient adherence. This contact lens design can potentially be used as a treatment for glaucoma and as a platform for other ocular drug delivery applications," said Joseph Ciolino, lead author of the paper.
The contacts were designed with materials that are FDA-approved for use on the eye, researchers said.
The latanoprost-eluting contact lenses were created by encapsulating latanoprost-polymer films in commonly used contact lens hydrogel.
"The lens we have developed is capable of delivering large amounts of drug at substantially constant rates over weeks to months," said Professor Daniel Kohane, director of the Laboratory for Biomaterials and Drug Delivery at Boston Children's Hospital.
In vivo, single contact lenses were able to achieve, for one month, latanoprost concentrations in the aqueous humour that were comparable to those achieved with daily topical latanoprost solution, the current first-line treatment for glaucoma, researchers said.
The lenses appeared safe in cell culture and animal studies. This is the first contact lens that has been shown to release drugs for this long in animal models.
The newly designed contact lens has a clear central aperture and contains a drug-polymer film in the periphery, which helps to control drug release.
The lenses can be made with no refractive power or with the ability to correct the refractive error in near sided or far sided eyes.
"A non-invasive method of sustained ocular drug delivery could help patients adhere to the therapy necessary to maintain vision in diseases like glaucoma, saving millions from preventable blindness," Ciolino said.